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OJVRTM
Online Journal of Veterinary
Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 29 (7): 402-409, 2025.
Salinomycin toxicosis in calves.
Rajaian H, Nazifi S, Mansourian M, Sepehrimanesh M,
Poorbaghi SL, Ghezelbash A.
Departments of Pharmacology and Clinical
Pathology, School of Veterinary Medicine, Shiraz University, Shiraz and Department of Veterinary
Medicine, Islamic Azad University of Bojnourd,, Iran
ABSTRACT
Rajaian
H, Nazifi
S, Mansourian M, Sepehrimanesh M, Poorbaghi SL, Ghezelbash A, Salinomycin toxicosis in calves, Onl J Vet
Res., 29 (7): 402-409, 2025.
We report intoxication in 90-130kg calves in 9 males given 4 or 5mg/kg
oral salinomycin and 4 females given 4mg/kg twice
daily for 2 consecutive days. Necropsy revealed congestion and edema of
skeletal muscles, swelling and hemorrhage in peripheral lymph nodes,
hydrothorax, and hydropericardium, petechial
hemorrhages in fat tissues of heart base, severe pulmonary congestion and
edema, large pale kidney and swelling of liver with mild to moderate yellowish
appearance. Histopathologic examination revealed pulmonary congestion and edema
with hyalinized thrombi in some of capillaries,
myocardial degeneration and necrosis without any inflammatory reaction.
Hepatocytes, renal tubules, sciatic nerves, and muscles were among other
tissues that showed histological changes.
Key words:
Salinomycin toxicosis, Pathological
lesions, Calves.
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