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OJVRTM

 Online Journal of Veterinary Research©

Volume 18(1):20-28, 2014. Redacted 2017.

Effect of oral salinomycin on inflammatory markers in sheep

 

Saeed Nazifi1, Hameed Rajaian2, Ali Hajimohammadi1, Elham Hashemi3, Maryam Ansari-Lari4

 

1Department(s) of Clinical Sciences, 23Basic Sciences and 4Food Hygiene and Public Health,  School of Veterinary Medicine, Shiraz University, Shiraz, Iran

 

ABSTRACT

 

Nazifi S, Rajaian H, Hajimohammadi A, Hashemi E, Ansari-Lari M., Effect of oral salinomycin on inflammatory markers in sheep, Onl J Vet Res., 18(1):20-28, 2014. Salinomycin, an ionophore with antimicrobial properties is used as a dietary growth promoter in ruminants and coccidiostat in chickens. Overdosage can lead to toxicity. The acute phase response is a nonspecific inflammatory reaction of the host occurring briefly after any tissue injury and includes changes in the concentration of plasma proteins identified as acute phase proteins (APPs). Changes in APPs plasma concentrations during experimental toxicosis with salinomycin in sheep is reported. Groups of 4 sheep each were given 20 ml saline (controls), or were orally administered 1 mg/kg salinomycin twice a day for two days or 2, 3 and 4 mg/kg salinomycin once a day for two days. Blood samples were collected  at 2, 5, 8, 14 and 21 days after salinomycin administration for assay of Hp, SAA, Fib, Cp, TNF-α, INF-γ, total sialic acid, lipid-bound sialic acid and protein-bound sialic acid concentrations. Results show a significant increase in all measured variables in salinomycin treated groups compared to control group (P<0.05). Increased serum amyloid A in sheep treated with salinomycin was more significant compared to other APP’s but no relationship was found between time or treatment.

 

Keywords: Salinomycin, Acute phase proteins, Inflammatory cytokines, Sheep.

 

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