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OJVRTM

 Online Journal of Veterinary Research©

 

Volume 18(5): 405-414, 2014. Redacted 2017.


Effect of salinomycin on tetracycline resistance in E. coli

 

M Dehghani1, S Hosseinzadeh2, H Rajaian1, SS Shekarforoush2, Y Zolghadri1 and J Jalaei1

 

1Department(s) of Basic Science and 2Food Hygiene, School of Veterinary Medicine, Shiraz University, Iran

 

ABSTRACT

 

Dehghani M, Hosseinzadeh S, Rajaian H, Shekarforoush SS, Zolghadri Y, Jalaei J., Effect of salinomycin on tetracycline resistance in E. coli, Onl J Vet Res., 18(5): 405-414, 2014.  Increasing rates of tetracycline resistance in animals is being transmitted to humans.  tetA is the most prevalent resistant plasmid in E. coli with a prevalence rate of 62 % based on MIC and gene screening. Ionophores used as food additive to promote growth are reported to transmit antimicrobial resistance genes such as tetA in bacteria. A possible interaction of salinomycin with tetracycline is described using in-vitro real time RT-PCR. Results suggest that the growth of tetracycline resistant E. coli was significantly reduced at 100 µg/ml of tetracycline in salinomycin exposed bacteria. Salinomycin decreased the relative transmission of the resistance genome (P < 0.001).

 

Keywords: Salinomycin, E. coli, Antibiotic resistance.


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