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OJVRTM

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

 Volume 30 (1): 50-58, 2026.

 

      Lymphocyte response to concanavalin A by muramyl dipeptide in birds with salmonellosis.

Nagaraja TR, Raghu TK,  Kumar PA, Mishra SC.

Project Directorate on Animal Disease Monitoring and Surveillance Hebbal, Bangalore, India.

 

ABSTRACT

Nagaraja TR, Raghu TK, Anand Kumar P, Mishra SC., Lymphocyte reponse to concanavalin A by muramyl dipeptide in birds with salmonellosis.  Onl J Vet Res., 30 (1): 50-58, 2026., We evaluated intestinal lymphocyte mitogenic reactivity to concanavalin A during Salmonella enteritidis in chickens by MTT colorimetric blastogenesis. Compared with controls, proliferation in infected chicks did not change by 24h or 7 days after infection. However, administration of muramyl dipeptide boosted (P < 0.01)  mitogenesis of lymphocytes in uninfected and infected chicks by 8 days. Lymphocytes from uninfected or infected chicks, treated with SE-ILK 24 hr before infection enhanced (P < 0.01) proliferative response at 48 hr and 8 days PT.

Key words :  Intestinal intraepithelial lymphocytes ; Mitogenic reactivity; lymphokines ; Muramyl dipeptide ; Salmonella Enteritidis ; chicken


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