©2023-2035 All
Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form
except for your own personal use. All other usage or distribution is illegal
under international copyright treaties. Permission to use any
of these pages in any other way besides the before mentioned must be gained in
writing from the publisher. This article is exclusively copyrighted in
its entirety to onlinejournals@gmail.com publications..
This article may be copied once but may not be, reproduced or re-transmitted without the express
permission of the editors. Linking: To link to this page or any pages linking
to this page you must link directly to this page only here rather than put up
your own page.
OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 28(4): 220-229,
2024
Murray LE, Dalal
SJ, Rico PJ, Chenault VM
1
Department of Laboratory Animal Medicine, Uniformed Services
University of the Health Sciences,, 2 Veterinary Medicine and
Surgery Branch USAMRICD and 4 U.S.
Food and Drug Administration Center for Devices and Radiological Health Office
of Science and Technology.
SUMMARY
Murray LE, Dalal
SJ, Rico PJ, Chenault M, E
Estrus in rats with diabetes mellitus,
Onl J Vet Res 28(4): 220-229, 2024. Psammomys obesus fat sand rat is a wild desert
rodent in the gerbil family that can develop diabetes when fed high calorie
diets. We compare low versus high calorie sand rat chow diets effects on
estrous cycle length. For this study we developed a vaginal epithelial
cell classification to assist us to compare the length of the estrous cycle and
vaginal cytology in the normal and diabetogenic sand
rats. We found estrous cycles over 10 day period 1.5±1.1 for normal and
1.6± 0.8 for diabetogenic sand rats and length of cycle
4.0±0.9 in normal and 4.8±0.7 days diabetogenic rats.
Proestrus commenced with diminishing to few PMN’s and
increasing numbers of parabasal cells. Overall,
a mixture of parabasal, intermediate cells and some
squamous epithelial cells characterize proestrus.
Our data indicated that in both groups when parabasal
cell numbers started to increase from 0 – 5 % to 30 % and above with
corresponding decrease in neutrophils from 70-80 % to 50 % then proestrus ensued within 24 hrs. We found no statistically
significant differences in estrous between any groups similar to those reported
by others. However, we described the vaginal cytology for the normal and diabetogenic sand rats for the different stages of the
estrous cycle and found no significant difference in estrous cycle
length.
KEY WORDS: Sand Rat,
Diabetes, Estrous Cycle.
FULL-TEXT (SUBSCRIBE OR
PURCHASE TITLE)