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OJVRTM
Online
Journal of Veterinary Research©
Volume 18(9): 727-734,
2014.
Effect of oral silymarin
on body weight, blood glucose and vitamin A, C and E levels in diabetic male Sprague Dawley rats
Javad Sajedianfard1, Saeed
Nazifi2, Hoseinali Shamsaei1
1Department(s)
of Physiology, 2Clinical Studies , School of Veterinary Medicine, Shiraz University,
Iran
ABSTRACT
Sajedianfard J, Nazifi S, Shamsaei H., Effect of
oral silymarin on body weight, blood glucose and
vitamin A, C and E levels in diabetic male Sprague Dawley rats. Onl J Vet Res., 18(9): 727-734
2014. Groups of 10 male diabetic rats each
were gavaged 100, 175 or 250 mg/kg sylimarin for 14 days. Controls were normal or diabetic
rats gavaged with saline for the same period.
Diabetes was induced by IP injection of 50mg/kg streptozotocin. Weight and blood glucose were measured before
and 3, 7 and 14 days after treatments. Blood samples were collected by heart
puncture. Average weight increased and blood glucose decreased in treated rats.
Vitamin A and C increased whereas
vitamin E decreased in a dose-dependent manner in treated rats. Results suggest
that high therapeutic doses of silymarin may alter body weight, glucose and serum antioxidants
in diabetic rats.
Keywords: Silymarin, Diabetes mellitus, Vitamins, Antioxidant .
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