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OJVRTM
Online Journal of Veterinary Research ©
Volume 14 (2): 227-232, 2010. Redacted
2017.
Identification of
single nucleotide variations in CYP1A1 gene
in repeat breeding cattle
Thanislass J1 (PhD) and Lydia Dhanammal2
(PhD).
1Department of Veterinary Biochemistry, 2Department
of Animal Genetics and Breeding, Rajiv Gandhi College of Veterinary and Animal
Sciences, Pondicherry-605009, India
ABSTRACT
Thanislass J, Dhanammal
L., Identification of single nucleotide variations in CYP1A1 gene in repeat
breeding cattle, Online J Vet Res, 14 (2): 227-232, 2010. CYP1A1
gene may affect hydroxylation of estrogen and thus, repeat breeding in cattle.
Ten normal and 20 repeat breeder Bos indicus were used to determine nucleotide transitions
from T à
C and from Aà
G in Exon 7 of the CYP1A1 gene.
Transitions found were non-synonymous single nucleotide polymorphisms resulting
in amino acid change from Tyrosine to Histidine and Isoleucine to Valine,
respectively. This transition in cattle may affect estrogen and thus, the
repeat breeding syndrome.
Key Words: CYP1A1,
SNP, Repeat Breeding, ASPCR, Estrogen
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