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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 26 (10): 770-776, 2022.
Diagnosis
of equine and bovine cutaneous melanoma and squamous cell carcinoma
by staining and
immunohistochemistry.
Farhang Sasani, Javad Javanbakht, Mehdi Aghamohammad Hassan, Farajollaheh
Adibhashemi, Soheila Hemmati.
Faculty
of Veterinary Medicine, Tehran University, Iran.
ABSTRACT
Sasani
F, Javanbakht J, Hassan MA, Adibhashemi
F, Hemmati S., Diagnosis of equine and bovine cutaneous melanoma and squamous cell
carcinoma by staining and immunohistochemistry, Onl J
Vet Res., 26 (10): 770-776, 2022. We report diagnoses for cutaneous
and squamous cell carcinomas from skin of horses and cattle by
hematoxylin-eosin, Fontana-Masson, melanin bleach, S-100 immunochemistry and
HMB45 antigen stains. Serial 5µm-thick sections were cut from routine
formalin-fixed paraffin blocks of squamous cell carcinomas and melanomas from 6 horses and by hematoxylin-eosin stain. S-100
protein and HMB45 tests confirmed 6 of 9 tumors whereas 3 were doubtful. By
Fontana-Masson silver and melanin bleaching methods all tumors tested positive.
However for squamous cell carcinoma the 3 tests were negative. Diagnosis of
suspicious melanoma tumor cases should be confirmed and reconfirmed by staining
and immunohistochemistry.
Key words:
Melanoma, Squamous Cell Carcinoma, HMB45 antigen, S-100 protein.
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