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OJVRTM
Online Journal of
Veterinary Research©
Volume 21(11):700-706, 2017.
Effect of
Stevia rebaudiana aqueous extract cream on wound
healing in Sprague-Dawley male rats
Fariba Najafi1, Reza Tahvilian2, Hooshmand
Farhadi3, Akram Zangeneh4, Narges Souri3, Chenoor
Poorshamohammad3,
Marziye-Sadat Hosseini3, Rohallah Moradi2,
Mohammad Mahdi Zangeneh3*
Department(s) of 1Dermatology,
School of Medicine, 2Research Pharmaceutical Center, School of
Pharmacy, Kermanshah niversity of Medical Sciences,
Kermanshah, Iran. Department(s) of 3Clinical
and 4Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. *Corresponding
Author: Mohammad Mahdi Zangeneh *Email:
m.mahdizangeneh@gmail.com
ABSTRACT
Fariba N, Tahvilian
R, Farhadi H, Zangeneh A, Souri N, Poorshamohammad C, Hosseini MS, Moradi
R, Zangeneh MM., Effect of Stevia rebaudiana
aqueous extract cream on wound healing in Sprague-Dawley male rats, Onl J Vet Res., 21(11):
700-706, 2017. Effects of aqueous extract of Stevia rebaudiana (SR) on wound healing markers in
male rats is described. Full-thickness 2X2 cm excisional wounds were induced on the back
of 32 euthanized rats. After wounding, groups of 8 rats each were treated daily for 20
days with 1ml Eucerin, 1ml Eucerin
3% tetracycline or 1ml Stevia leaf aqueous extract 10% suspended in 90g Eucerin. Controls were wounded but not treated.
Rodents were euthanized 20 days post-injury (DPI) and wounds
assessed grossly and microscopically for alignment of healing tissue,
re-epithelization, and blood elements. We found arrangement of healing
tissue, re-epithelialization and epithelial formation different compared with
controls. Findings suggested that SR decreased the number of total cells,
lymphocytes and increased the blood vessels, fibrocytes
and fibroblasts by 20 day (p<0.05). Findings suggested that aqueous extracts
of Stevia affected wound healing in
rats.
Keywords: Stevia rebaudiana; aqueous extract; wound healing; rat.
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