MAIN


©1996-2009 All Rights Reserved. Online Journal of Bioinformatics . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJB®

 

Online Journal of Bioinformatics ©

 7 (1) : 35-45, 2006


Comparative structure analysis of chorismate synthase 

  

Marla S , Yalamanchili HK,  Gelli P, Singh HK, Praveen G, Ghatta G, Srikanth S, Goutham K.

 

Biotechnology and Bioinformatics Department, JayaPrakash University of Information technology, Solan, H.P.173215, India.


ABSTRACT

 

Marla S , Yalamanchili HK,  Gelli P, Singh HK, Praveen G, Ghatta G, Srikanth S, Goutham K, Comparative structure analysis of Chorismate synthase, Online J Bioinformatics, 7 (1) : 35 - 45, 2006. This work compares chorismate synthase structure in  various  microorganisms. The enzyme is essential in the shikomate pathway  in  bacteria, fungi and plants, but not in mammals. It is a useful target for drug design inhibiting functional  pathways with chemotherapeutic effects. Binding of essential co-factors Flavin mononucleotide (FMN) and 5-enolpyruvil shikomate-3-phosphate(EPSP) affects its activity. The results of  FMN  structure analysis and in various microorganisms are presented. Comparative modeling  and extent of structure similarities between  H. pyroli and P. rumnicola were performed using alpha and beta fold patterns, FMN binding and main chain configuration residues. Active sites for binding of  FMN were detected.  Phylogeny analysis was evaluated in various microorganisms.

 

Key words: Chorismate synthase, flavin mononucleotide, Binding sites, Helicobacter pyroli, Prevotella rumnicola.


MAIN

 

FULL-TEXT (SUBSCRIPTION)