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OJVRTM
Online
Journal of Veterinary Research©
Volume 21(5):207-215,
2017.
Effects of taranjabin manna on
gastrointestinal tract in Wistar rats.
1Noorbakhsh MF, 2Afkhami Gol A, 2Kazerani
HR*
1Graduate School of Veterinary Medicine, 2Department of Pharmacology and Physiology, School
of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.*
Corresponding author: kazerani@um.ac.ir
.
ABSTRACT
Noorbakhsh MF, Afkhami Gol
A, Kazerani HR., Effects of taranjabin
manna on gastrointestinal tract in Wistar rats, Onl J Vet Res., 21(4):207-215, 2017. Taranjabin manna
(wet honey) has been used as a laxative, antipyretic, expectorant and to
treat/prevent newborn jaundice. Groups of rats (n=7) were gavaged
taranjabin manna or placebo (controls) and number,
weight and water content of fecal pellets were determined for 24h. Osmotic
laxative effect in rats (n=5) was determined by injecting 0.5ml taranjabin solution, lactulose or saline into separate 4cm
jejunum segments and measuring volume of contents in each segment after 1h.
Intestinal transit time was evaluated in fasting rats (n=32) given taranjabin or lactulose by the phenol red test. Oral
administration of taranjabin increased (p<0.001)
number of fecal pellets and their percentage of water, but had no effect on
intestinal transit time. Volume of contents in jejunum segments increased
(P<0.05) with taranjabin or lactulose compared
with placebo. Taranjabin may exert a laxative effect
partly via osmotic infiltration of fluids into the intestine partly masked by
delayed emptying of cecum contents.
Keywords: Laxative, prokinetic, taranjabin. Normally
distributed raw data files provided for independent analyses.
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