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OJVRTM
Online
Journal of Veterinary Research©
Volume 20(9):578-585, 2016.
Effects of Artemisia sieberi and terbinafine on Microsporum canis on
guinea pigs.
Hamid Alidoosti1, Siamak Mashhady Rafie1, Mansour Bayat2
1Department(s) of
Small Animal Medicine, 2Mycology, Science and Research branch,
Islamic Azad University, Tehran, Iran;
ABSTRACT
Aldosti H, Rafie SM, Bayat M., Effect of Artemisia sieberi
and Terbinafine 1% on Microsporum canis
infection on Guinea pigs, Onl J Vet Res.,
20(9):578-585, 2016. Effects of Artemisia sieberi essence
or Terbinafine 1% cream on experimental dermatophytosis
caused by Microsporum canis in
guinea pigs are described. Groups of 6 guinea pigs each were treated 5 days
after infection every 12 hours for 40 days with Terbinafine 1% cream or A. sieberi nano-essence. Controls were non-treated infected and
non-infected saline guinea pigs. Animals were
evaluated clinically and laboratory tests recorded in SPSS. Clinical scores
in guinea pigs given nano-essence at 5, 12 and 19d were
undistinguishable from those given terbinafine but from day 26 to 40 were
significantly less in those treated with nano-essence.
Microsporum canis cultures were
negative at 33, 40 and 50d in treated and negative controls. Results suggested that Artemisia sieberi essence may
improve treatment of Trichophyton Microsporum canis.
KEY-WORDS:
Nano-essence, Guinea pig, Microsporum canis,
Terbinafine, Artemisia sieberi.
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