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OJVRTM
Online Journal of
Veterinary Research©
Volume 20(4):254-263, 2016.
Acute dermal toxicity of Terminalia catappa
leaf extract in Sprague Dawley rats
Farhan Hanif
MR DVM1, Hazilawati H DVM MVSc PhD2*, Rosly SM
DVM MSc3, Nurul SAS BSc,
Noordin MM DVM
MSc PhD2, Shanmugavelu S DVM MPhil PhD3.
1Department of Paraclinical
Studies, Faculty of Veterinary Medicine, Universiti
Malaysia Kelantan, Pengkalan Chepa,
16100, Kota Bharu, Kelantan. 2Department of Veterinary Pathology and
Microbiology, Faculty of Veterinary Medicine, Universiti
Putra Malaysia, 43400, Serdang, Selangor.3Animal
Science Research Centre, Malaysian Agricultural Research and Development Institute
(MARDI) Headquarter, 43400, Serdang, Selangor
ABSTRACT
Hanif F, Hazilawati H, Rosly SM, Nurul SAS, Noordin MM, Shanmugavelu S.,
Acute dermal toxicity of Terminalia catappa leave extract in Sprague Dawley rats. Onl
J Vet Res., 20(4):254-263,
2016. Terminalia catappa Combretaceae spp exists in
tropical areas including Malaysia and may affect dermal healing processes.
Acute dermal toxicity of ethanolic extract of T. catappa leaves in female
Sprague Dawley rats is described. The study was conducted under OECD guideline
No. 402 with 5 groups of 6 rats each, topically applied Terminalia catappa extract of 2.5%, 5%
and 10% in paraffin, on shaved dorsal skin surface once on Day 1. Controls were
applied paraffin or not treated. Rats were then monitored 14 days for changes
in appearance, behavior, pain and illness. Compared with controls (p>0.05), there was no mortality,
sudden change in condition or behavior, body or kidney and liver weight, haematology, or serum biochemistry in any group.
Keywords:
alternative medicine, haematology, serum
biochemistry, organ weight.
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