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OJVRTM
Online Journal of Veterinary Research©
(Including Medical
and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28(4): 178-189,
2024.
Molecular
Sequence Mycobacterium Tuberculosis and
Leprae drug targets.
Lakshmi
Pillai, Usha Chouhan.
Department of Computational and
Integrated Science, MANIT, Bhopal.
ABSTRACT
Pillai L, Chouhan
U., Molecular Sequence Mycobacterium Tuberculosis and Leprae
drug targets, Onl J Vet Res., 28(4):178-189, 2024. Genus Mycobacterium consists of pathogenic M.
tuberculosis and M. leprae with different proteins but
similar characteristics. We describe
computational classification of M.
tuberculosis H37Rv and Leprae drug targets based on literature and pathway analysis.
We found 28 amino acid pathways for Mycobacterium
leprae and 38 for M. tuberculosis. We determined pathways with similarity and dissimilarities between the bacteria but M.
leprae metabolized glucose for energy. Pseudogenes
in M. leprae corresponding to genes in M. tuberculosis enable breakdown of other
carbon source acetate and galactose. More pathways in M. tuberculosis suggesting more unknown genes in this organism
compared with M. leprae.
Keywords: Mycobacterium
Tuberculosis, M. Leprae, pathway analysis, fibrosis,
granuloma.
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