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OJBTM
Online
Journal of Bioinformatics ©
Volume 15 (2): 191-197, 2014.
Structure
of tumor suppressor gene protein (PTEN) by homology modelling.
Babita Rathore1, Madhvi Shakya2
1Department(s) of Bioinformatics and 2Mathematics, MANIT,
Bhopal- 462051, India
Rathore B, Shakya
M., Structure
of tumor suppressor gene protein (PTEN) by
homology modelling, Onl J Bioinform.,
15
(2): 191-197, 2014. PTEN (Phosphatase and Tensin homolog deleted on chromosome 10), a tumor
suppressor gene mutates in human tumors including melanoma. PTEN regulates cell
growth, apoptosis and proliferation. De-regulation of this protein is also
involved in several other diseases. Homology modeling was done with Protein
Structure Prediction Server (PS2), energy minimized with GROMACS, and assessed
by PROCHECK and WHATCHECK. A 3D
structure of PTEN constructed through homology modelling is shown.
Keywords: Melanoma,
PTEN, Homology Modelling.