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OJVRTM
Online
Journal of Veterinary Research ©
(Including Medical and
Laboratory Research)
Established
1994
ISSN 1328-925X
Volume
27 (11): 587-593, 2023.
Effect of 30 day gavage tungsten alloy and
cobalt on mice tissues.
Robert V Hawley,
Pedro J Rico,
Ranjana Verma, Eric
Lombardini, Zygmunt Galdzicki
Uniformed Services, University of Health Sciences, USA.
Hawley RV, Rico PJ, Verma
R, Lombardini E, Galdzicki
Z., Effect of 30 day gavage tungsten alloy and cobalt on mice tissues, Onl J Vet Res., 27 (11): 587-593, 2023. We
report effects of 100 µg/g tungsten alloy gavaged daily
30 days on tissues of C57BL/6 mice. Shams were gavaged
100 µg/g/day of cobalt chloride and controls were given water. At conclusion, mice were euthanized and
tissues excised for microscopy. We found no neoplastic changes but did find
gastrointestinal lesions in 63% gavaged tungsten and
24% given cobalt (P < 0.001) and urogenital pathology in 35 and 32% P <
0.04), respectively. Controls had severity score = 1 but on a 6 point scale
cobalt group scored 2.5 and tungsten 3.8. We found mild to moderate hepatic
glycogenosis and lipoidal degeneration with rare
hepatocellular centronuclear chromatin condensation
in treated mice. However, only 24%
cobalt treated mice had gastrointestinal (GI) lesions. In those gavaged cobalt or tungsten, urogenitary
tract lesions ranged 32-35% with marked seminiferous epithelial degeneration
and atrophy with giant cells. In lungs we found alveolar histiocytosis with or without concurrent bronchopneumonia
and mild eosinophilic crystalline pneumonia.
Cardiovascular, endocrine, musculoskeletal,
integumentary, special senses and neurological appeared normal.
Key
words: Tungsten alloy (WA), tungsten (W), gastrointestinal (GI), and
urogenital (U/G) systems.
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