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 OJVRTM

Online Journal of Veterinary Research © 

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 28 (2): 61-69, 2024.

 Disposition of gatifloxacin after gavage in healthy and hepatopathic turkeys.

 

Kaushik Sarkar, Kumar Roy.

 

Department. of Pharmacology and Toxicology, College of Veterinary Science, Ranchi, India

 

ABSTRACT

 

Sarkar K, Roy K., Disposition kinetics of gatifloxacin after single oral administration in healthy and hepatopathic turkeys. Onl J Vet Res., 28 (2): 61-69, 2024. We report disposition kinetics of gatifloxacin single dose oral administration 20 mg/kg in 6 normal and 6 paracetamol induced hepatopathic 1-1.5 year 3-4 kg turkeys. Plasma Cpmax  of 5.94±0.29 µg/ml occurred at 2h in hepatopathic and 5.33±0.26 µg/ml in normal turkeys whereas therapeutic levels remained 48 and 24h, respectively. Plasma t½β was extended to 11.52±0.20h compared with normal turkeys (6.26±0.45 h) but plasma ClB was 6.25±0.35 ml/kg/min compared with healthy ones (8.28±0.46 ml/kg/min). Mean Vdarea of gatifloxacin of 6.23±0.36 L/kg was higher (p<0.05) compared to healthy turkeys (4.94±0.28 L/kg). Results suggest that 12.52 mg/kg oral gatifloxacin could be administered at 88h intervals in hepatopathic turkeys.

 

Key words: Disposition kinetics, gatifloxacin, turkeys, hepatopathy, oral.

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