1994-2020. All Rights Reserved. Online Journal of Veterinary Research. You may not store
these pages in any form except for your own personal use. All other usage or
distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR publications. This
article may be copied once but may not be, reproduced or re-transmitted without
the express permission of the editors.
OJVRTM
Online Journal of Veterinary
Research©
(Including Medical and Laboratory
Research)
Established 1994
ISSN 1328-925X
Volume
22 (10):967-973, 2018.
Effect of glimepiride,
bromocriptine or fluoxetine on weight, fasting blood sugar, glucose, insulin,
insulin
resistance and prolactin on type 2 diabetes in female rabbits.
DA Abbas, Areej Basil Abbas.
Department of
Pharmacology, College of Veterinary Medicine, Baghdad University¹‘²
ABSTRACT
Abbas
DA, Abbas AB., Effect of glimepiride, bromocriptine or fluoxetine on weight,
fasting blood sugar, glucose, insulin, insulin resistance and prolactin on type
2 diabetes in female rabbits, Onl J Vet Res., 22
(10):967-973, 2018. Three groups of 5 mixed breed 1.2-1.42 Kg female
rabbits each were induced with type 2 diabetes by a single intraperitoneal injection
of 120mg/kg alloxan and 50mg/kg nicotinamide. The
rabbits were then treated orally daily for 60 days with 0.11mg.kg glimepiride
(Group 1), with 0.04mg/kg bromocriptine (2) mg/kg) or 0.29 mg/kg fluoxetine
(3). Controls were untreated diabetic rabbits (4) or only given water (5). We
monitored body weights, serum prolactin, fasting blood sugar (FBS), insulin and
insulin resistance at 30 or 60 days after induction of type 2
diabetes. Diabetes reduced (P
< 0.05) body weight 4-12% up to 30 days in all groups except water controls.
By 60 days in those given Glimeridide with
Bromocriptine and diabetic controls, weights still remained similar to
pre-induction values whereas in water controls by 30 and 60 days body weights
had increased 5-20% (P < 0.05). In rabbits given Glimeridide
with fluoxetine, by day 60 weights were maintained but did not increase.
Fasting blood sugar increased (P < 0.05) 57-76% just after induction in all
rabbits but by Day 60 Glimiride had had no effect. In
contrast, by day 60, Glimepiride with Bromocrytine
reduced (P < 0.05) sugar by 15% and with Fluoxetine 9%. In diabetic
controls, glucose increased (P < 0.05) 61% but in water controls declined 23%.
Glimiride increased blood insulin 43% and with bromoceriptine 24% and fluoxetine 37%, (P< 0.05), but in
diabetic or water controls there were no changes. We found large declines (P <
0.01) in insulin resistance values (after induction of type 2 diabetes), due to
glimeridide with bromocriptine (-57%) or fluoxetine
(-30%) but none with glimeridide alone. Neither
controls showed any change in insulin resistance compared with pre-induction
values. By day 60, Prolactin declined 27% in rabbits given Glimiride
with Bromocriptine, but increased 27% in those given fluoxetine: In non-treated
diabetic control this value increased by 50%
Key word: DM2, glimepiride,
bromocriptine, fluoxetine, prolactin, insulin resistance.
FULL-TEXT (SUBSCRIPTION OR PURCHASE
TITLE)