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OJVRTM
Online Journal of
Veterinary Research©
Volume
18(2): 109-115, 2014. Redacted 2017.
Toxicology of urotropine
in chicken embryo
Hadi Tavakkoli1,
Amin Derakhshanfar2, Sajedeh Salandari3
1,3Department(s) of Avian Medicine, School of Veterinary Medicine, Shahid Bahonar University of
Kerman, 2Center of comparative & experimental medicine, School of medicine,
Shiraz University, Iran".
ABSTRACT
Tavakkoli H, Derakhshanfar A, Salandari S., Toxicology of urotropine
in chicken embryo, Onl J Vet Res., 18(2): 109-115,
2014.
Macroscopic and microscopic changes in chicken embryos
exposed to urotropine is described. Groups of
10 fertile chicken eggs each were injected 10, 100, 200 and 300 mg/egg urotropine at the 4th day of incubation. Control
groups of 10 eggs each were injected with an empty needle into the yolk sac, or
not treated, or injected 0.5ml/egg phosphate buffered saline. Macroscopic
abnormalities in size, color or external body features in embryos were
accompanied by pathological changes in the embryonic kidney. Alterations
occurred in a urotropine
dose-related manner and higher urotropine levels were
related with marked embryonic death. The results suggest that urotropine at high concentrations are toxic to chicken
embryos.
Keywords: Chicken, Egg,
Embryo, Toxicopathology, Urotropine