Volume 23 (4):337-344, 2019.
Effect of oral PLGA/TPGS nanoparticles on stability
of vorapaxar and atherosclerosis markers in male albino
rats.
Adnan M Jasim1, Huda Falah Hasan Alqaraghuli2.
College(s) of Veterinary Medicine, 1University
of AL-Qassim, 2University of Baghdad, Iraq.
ABSTRACT
Jasim AM, Hasan Alqaraghuli
HF., Effect of oral PLGA/TPGS
nanoparticles on stability of vorapaxar and
atherosclerosis markers in male albino rats, Onl J
Vet Res., 23 (4):337-344, 2019.PLGA-TPGS
nanoparticles are used as polymeric matrix to deliver drugs. We describe effective
dose (ED50-99) of vorapaxar from a PLGA-TPGS matrix,
stability and effect on atherosclerosis platelet and cholesterol markers in
male albino rats. Groups of 6 rats with or without atherosclerosis were gavaged ~0.04, 0.08, 0.2, 0.4 and 0.9 mg/kg vorapaxar with or without PLGA-TPGS nanoparticle matrix
daily for 30 days to determine ED50-99 from probit
analysis. Controls with or without atherosclerosis had no treatment or given
distilled water. We found that TPGS-PLGA
with nanoparticles < 200nm loaded with Vorapaxar were
stable. Given alone the ED50 for vorapaxar was ~0.07,
ED90, 0.4 and ED 99 1.6mg/kg but given with TPGS-PLGA was 0.07, 0.1 and 0.17mg/kg,
respectively. Compared with healthy controls, we found rises (P < 0.05) in
platelets and serum cholesterol in atherosclerotic controls and in those given vorapaxar. In rats given vorapaxar
in nanoparticles we found significant reduction in platelets and serum
cholesterol compared with those given only vorapaxar.
Key word : Vorapaxar,
TPGS/PLGA, nanoparticles, ED50-99.
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