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OJBTM
Online Journal of Bioinformatics ©
Volume 10 (1):93-97, 2009
In silico identification of
small interfering RNA (siRNA)
in the putative genes of White Spot Syndrome virus.
Singh V, Somvanshi
P
Bioinformatics Centre,
ABSTRACT
Singh V, Somvanshi
P, In silico identification
of small interfering RNA (siRNA) in the putative
genes of White Spot Syndrome virus. Online J Bioinformatics, 10 (1):93-97,
2009. White spot syndrome
virus (WSSV) is an important shrimp pathogen causing extensive economic losses
worldwide. Currently, no efficient approach is available to control this virus.
An innovative tactic was employed for controlling the virus with small interfering
RNA (siRNA). It is a class of 20-25 bp
double-stranded RNA molecules which interferes with the expression of a
specific gene. Nine
significant putative genes encoding the virulence proteins from WSSV were used
for identification of siRNA and their verification
was done by in silico approach. The siRNA might be use for knockdown the WSSV and may also
helpful for designing the live attenuated vaccine for controlling infection in
shrimps.
Keywords: White spot syndrome virus, siRNA, pathogenesis, knockdown, vaccine