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OJVRTM
Online Journal of Veterinary Research©
Volume 26 (6): 470-476, 2022.
Effect of Zataria
multiflora boiss on intestinal ischemia-reperfusion
in rats.
Naghmeh Ghasemkhani DVM,
Omid Azari DVM PhD, Reza Kheirandish DVM PhD.
School of Veterinary Medicine, Shahid Bahonar University of
Kerman, Iran.
ABSTRACT
Ghasemkhani N, Azari O, Kheirandish R., Effect
of Zataria multiflora boiss
on intestinal ischemia-reperfusion in rats, Onl J Vet
Res., 26 (6): 470-476, 2022. Authors report effect of Zataria multiflora boiss (ZM) ethanol extract on
intestinal ischemia/reperfusion injury in male Wistar
albino rats. Groups of 5 rats each were gavaged 200
and 400 ppm ZM daily for 7 days ppm then subjected to 45 min ischemia followed
by 1h reperfusion by clamping and de-clamping abdominal aorta. Five shams were gavaged saline subjected to surgery without clamping and
controls clamped but not given ZM. After trials the jejunum was removed for microscopy
and injury scored 0 normal, 1-4 villi edema fragmentation or hemorrhage to 5
complete mucosal necrosis as per Chiu et al., (1970).
In clamped untreated controls we found
severe mucosal denudation or complete loss of villi and necrosis with score 4-5
whereas in treated non-clamped shams intestines remained normal. In rats gavaged ZM we scored lesions 1-4 and 1-3 but we found no
differences between these treated groups. Findings suggest that Zataria multiflora ethanol extract may reduce
lesions induced by ischemia.
Key words: Ischemia/reperfusion
injury, Zataria multiflora, Intestine, Rat.
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