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OJVRTM
Online
Journal of Veterinary Research©
Volume 24 (6):332-337, 2020.
Effect of Zingiber
officinale Roscoe extract on diarrhea in Wistar rats.
Ammar Khalid Hammad and Ali H. Saliem
College of Veterinary
Medicine, University of Baghdad, Iraq
ABSTRACT
Hammad AK, Saliem AH., Effect of Zingiber officinale Roscoe
extract on diarrhea in Wistar rats, Onl J Vet Res., 24 (6):332-337, 2020. We gavaged
2 groups of six 200-250g Wistar rats each with
diarrhea induced by castor oil with or without 100mg/kg Zingiber officinale Roscoe ethanolic extract daily for 5 days. Six controls were
given distilled water. To assess diarrhea, we counted wet droppings hourly 1-5
hours and then daily to 5 days. To evaluate empty and filled intestinal weights
we sacrificed another 18 rats treated as above after 2 hours to assess empty
and filled intestinal weights. The extract was positive for alkaloids,
flavonoids, steroids, carbohydrates, glycosides, phenolic compounds, tannins
and saponins but we found no amino acids or protein. Compared
with controls, rats given castor oil expelled liquid feces up to 3 h whereas those
given Zingiber officinale
Roscoe it reduced (P < 0.05) 46-100%, 5h to 5 days
after. Intestinal contents (g) reduced (P < 0.05) 58% in those given oil but
only 15% in rats given extract with oil. Intestinal volumes (ml) fell (P < 0.05)
63% in rats given castor oil but only 36% in those given the oil with extract.
Key
words: Diarrhea, Zingiber officinale,
rats.
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